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Targeted Sequencing Hero
Precision Genomics

Targeted Sequencing

Achieve ultra-deep resolution for low-frequency variants. From custom gene panels to clinical liquid biopsy, our targeted solution delivers precision where it matters most.

LoD 0.1%
Limit of Detection
Ultra-Deep Resolution

Focus Your Search.
Ignite Your Discovery.

While WGS and WES provide breadth, Targeted Region Sequencing provides the depth required for clinical-grade precision. By focusing on specific genomic subsets, we can achieve sequencing depths of 1000× to 10,000×, enabling the detection of rare somatic mutations that would be invisible in a standard genome run.

Our platform integrates Unique Molecular Identifiers (UMI) as a standard for low-frequency applications, ensuring that every variant called is a biological reality, not a sequencing artifact.

0.1% VAF
Sensitivity
up to 20,000×
Depth
UMI-Deduplicated
Correction

Pre-Designed & Custom Solutions

Select from our validated catalog or collaborate on a bespoke panel design.

Hereditary Disease Panels

Cardiology, Neurology, Rare Disease

Comprehensive scanning of known pathogenic loci with high uniformity across clinical targets.

EnrichmentHybrid Capture / WES-Backbone

Oncology Hotspot Panels

Solid Tumors, Hematology, ctDNA

Deep profiling of driver mutations (KRAS, EGFR, PIK3CA) with validated LoD down to 0.1%.

EnrichmentUltra-Deep Amplicon / UMI-Capture

Pharmacogenomics (PGx)

Drug Metabolism, Safety, Efficacy

Analysis of CYP450 and other ADME genes to guide personalized medication strategies.

EnrichmentTargeted Genotyping / ADME Focus

Hybrid Capture vs. Amplicon-Based

Feature MatrixHybrid CaptureTargeted Amplicon
Sequencing Depth100× - 1000×1000× - 5000×+
Target SizeUp to 20 MbMainly < 500 kb
Input DNA10ng - 100ng1ng - 10ng
Structural VariantsExcellent (Fusion/SV)Limited
Turnaround Time4 - 6 weeks2 - 3 weeks

The Strategic Advantage

Ultra-Deep Sensitivity (UMI)

Utilize Unique Molecular Identifiers (UMIs) to detect variants down to 0.1% VAF, effectively eliminating sequencing noise and PCR artifacts.

Liquid Biopsy & ctDNA

High-precision cell-free DNA (cfDNA) profiling for early cancer detection, minimal residual disease (MRD) monitoring, and treatment response.

Custom Panel Agnostic

Seamless design of custom hybridization-based or amplicon panels targeting hotspots, whole exons, or deep intronic variants.

Extreme Throughput Efficiency

Focus resources strictly on diagnostic regions of interest, allowing for massive sample multiplexing and lowest cost-per-target.

The Precision Pipeline

Core Pipeline (UMI-Based)

  • UMI-deduplication & Error Correction
  • High-sensitivity variant calling (SNV/InDel)
  • On-target/Off-target performance metrics
  • Customized clinical-grade annotation
  • Structural Variant (SV) & Fusion detection

Advanced Analytics

  • Minimal Residual Disease (MRD) monitoring
  • Mutational Signature analysis (SBS, DBS, ID)
  • Copy Number Variation (CNV) deconvolution
  • Clonal Evolution & Subclonal analysis
  • Trial matching & biomarker reporting

Standard Deliverables

Raw Data (FASTQ)
Full quality control reports included.
Aligned Data (BAM)
UMI-deduplicated and indexed.
Variant Call Format (VCF)
Annotated with ClinVar/COSMIC data.
Technical Report
Summary of coverage and variant stats.

Secure Encrypted Data Delivery

Technical Q&A

UMIs (Unique Molecular Identifiers) tag individual DNA molecules before amplification. During analysis, reads with the same UMI are collapsed into a consensus sequence, effectively filtering out errors introduced during PCR or sequencing. This allows us to reliably detect mutations as low as 0.1% frequency.

Secure Your High-Sensitivity
Genomic Data

Partner with our NGS specialists for custom panel design and liquid biopsy profiling with guaranteed ultra-deep sensitivity.

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