Focus Your Search.
Ignite Your Discovery.
While WGS and WES provide breadth, Targeted Region Sequencing provides the depth required for clinical-grade precision. By focusing on specific genomic subsets, we can achieve sequencing depths of 1000× to 10,000×, enabling the detection of rare somatic mutations that would be invisible in a standard genome run.
Our platform integrates Unique Molecular Identifiers (UMI) as a standard for low-frequency applications, ensuring that every variant called is a biological reality, not a sequencing artifact.
Pre-Designed & Custom Solutions
Select from our validated catalog or collaborate on a bespoke panel design.
Hereditary Disease Panels
Comprehensive scanning of known pathogenic loci with high uniformity across clinical targets.
Oncology Hotspot Panels
Deep profiling of driver mutations (KRAS, EGFR, PIK3CA) with validated LoD down to 0.1%.
Pharmacogenomics (PGx)
Analysis of CYP450 and other ADME genes to guide personalized medication strategies.
Hybrid Capture vs. Amplicon-Based
| Feature Matrix | Hybrid Capture | Targeted Amplicon |
|---|---|---|
| Sequencing Depth | 100× - 1000× | 1000× - 5000×+ |
| Target Size | Up to 20 Mb | Mainly < 500 kb |
| Input DNA | 10ng - 100ng | 1ng - 10ng |
| Structural Variants | Excellent (Fusion/SV) | Limited |
| Turnaround Time | 4 - 6 weeks | 2 - 3 weeks |
Simple End-to-End Workflow
Five seamless steps from sample submission to actionable clinical or research report.
Sample Submission & QC
Submit blood, plasma (cfDNA), FFPE, or extracted DNA. Rigorous initial QC for quantity and integrity.
Library Prep & Panel Enrichment
Target capture (hybridization) or amplicon enrichment with UMI tagging for ultra-deep sensitivity.
Ultra-Deep Sequencing
Sequencing on Illumina platforms (up to 20,000× depth) depending on the required limit of detection (LoD).
Bioinformatics & UMI Correction
Custom pipelines for UMI-deduplication, error correction, and high-sensitivity somatic or germline variant calling.
Secure Data Delivery
Delivery of raw FASTQ, BAM, VCFs, and comprehensive clinical/technical reports via secure portal.
Supported Sample Types & Requirements
Uncertain about your sample quality or low-input samples? Reach out — our team will assess and advise at no cost.
The Strategic Advantage
Ultra-Deep Sensitivity (UMI)
Utilize Unique Molecular Identifiers (UMIs) to detect variants down to 0.1% VAF, effectively eliminating sequencing noise and PCR artifacts.
Liquid Biopsy & ctDNA
High-precision cell-free DNA (cfDNA) profiling for early cancer detection, minimal residual disease (MRD) monitoring, and treatment response.
Custom Panel Agnostic
Seamless design of custom hybridization-based or amplicon panels targeting hotspots, whole exons, or deep intronic variants.
Extreme Throughput Efficiency
Focus resources strictly on diagnostic regions of interest, allowing for massive sample multiplexing and lowest cost-per-target.
The Precision Pipeline
Core Pipeline (UMI-Based)
- UMI-deduplication & Error Correction
- High-sensitivity variant calling (SNV/InDel)
- On-target/Off-target performance metrics
- Customized clinical-grade annotation
- Structural Variant (SV) & Fusion detection
Advanced Analytics
- Minimal Residual Disease (MRD) monitoring
- Mutational Signature analysis (SBS, DBS, ID)
- Copy Number Variation (CNV) deconvolution
- Clonal Evolution & Subclonal analysis
- Trial matching & biomarker reporting
Standard Deliverables
Secure Encrypted Data Delivery
Technical Q&A
Secure Your High-Sensitivity
Genomic Data
Partner with our NGS specialists for custom panel design and liquid biopsy profiling with guaranteed ultra-deep sensitivity.