DNA Methylation
Analysis Services
High-throughput epigenomic profiling using precision bisulfite conversion and targeted sequencing to identify DNA-protein interactions.
Revealing the Hidden
Epigenomic Landscape
Epigenomics is the study of alterations in an organism’s gene expression that do not involve changes to the underlying DNA sequence. Central to this is DNA methylation, a key mechanism of transcriptional regulation.
Our facility pairs high-throughput DNA sequencing with precision sodium bisulfite conversion, enabling the analysis of both methylated and unmethylated cytosines at single-base resolution.
Bisulfite Chemistry
Reliable conversion for base-level resolution.
Whole Genome Flow
Comprehensive mapping of every CpG site.
Protein-DNA Maps
Expert ChIP-Seq for binding site discovery.
HPLC Validation
Highly accurate measurement of 5mC/5hmC.
Epigenomic Analytical Capabilities
Whole Genome Bisulfite Seq (WGBS)
Get comprehensive, single-base resolution of DNA methylation patterns across the entire genome.
Targeted Bisulfite Sequencing
Precision-targeted approach to verify specific regions of interest found in genome-wide analyses.
ChIP-Sequencing Service
Identifying genome-wide DNA binding sites for transcription factors and chromatin-associated proteins.
5mC/5hmC Analysis
Differential detection and quantification of 5-methylcytosine and 5-hydroxymethylcytosine.
Sodium Bisulfite Conversion
Proven precision conversion of unmethylated cytosines to uracil while shielding methylcytosines.
CpG Site Level Analytics
Quantitative measurement of DNA methylation levels at specific genomic loci or promoter regions.
Bisulfite & Sequencing Pipeline
Sample Extraction
Isolating intact genomic DNA
Bisulfite Conversion
Cytosine-to-uracil transformation
Library Construction
NGS-ready template generation
Precision Sequencing
High-throughput data capture
Bioinformatics Analysis
CpG mapping & methylation scoring
5mC vs 5hmC DifferentiationPrecision Tech
"Our 5mC/5hmC sequencing service utilizes established, high-accuracy systems to differentially detect methylation states, providing a deeper layer of epigenomic insight beyond standard bisulfite conversion."
Where Epigenomics Powers Discovery
Mapping the regulatory landscape in health and disease.
Cancer Epigenetics
Developmental Biology
Environmental Epigenetics
Aging & Longevity
Biomarker Discovery
Transcriptional Regulation
Epigenetic Mastery
Our facility maintains ISO-certified protocols for bisulfite conversion, ensuring over 99% conversion efficiency while preserving template integrity.
Epigenomic Packages
Standardized profiling for research and clinical studies
Site Target
Bisulfite Validation
Epigenome Pro
Whole Genome Mapping
Interaction Plus
ChIP & Methylation
Mastering the
Methylome
Download our technical brochure to explore bisulfite conversion workflows, NGS platforms, and targeted methylation panels.